Diabetes and Cardiovascular

Studies at the Harvard School of Public Health and Johns Hopkins University have suggested that there is a direct correlation between low chromium tissue levels and the incidence of cardiovascular disease in people with diabetes.

Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes.

Chromium Picolinate and Biotin Combination Reduces Atherogenic Index of Plasma in Patients with Type 2 Diabetes Mellitus: A Placebo-Controlled, Double-Blinded, Randomized Clinical Trial.

The Effect of Chromium Picolinate and Biotin Supplementation on Glycemic Control in Poorly Controlled Patients with Type 2 Diabetes Mellitus: A Placebo-Controlled, Double-Blinded, Randomized Trial.

Effect of Chromium Picolinate/Biotin on Carbohydrate and Lipid Metabolism in a Rat Model of Type II Diabetes. Kazim, S., et al, ADA 2006, 1673-P

Long Term Supplementation of Combination of Chromium Picolinate and Biotin Improves Glycosylated Hemoglobin in Type 2 Diabetes Mellitus. Albarracin, C., et al, ADA 2006; 1649-P

Improved Glycemic Control After Diabetes Education and Chromium Picolinate/Biotin Supplementation in Type 2 Diabetes: results from Patients Experience Pilot Program. Juturu, V, Trace Elements Electrol

Chromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitus. Vrtovec, M., et al,Am Heart J, 2005; 149 (4):632-6

Supplementation with chromium picolinate recovers renal Cr concentration and improves carbohydrate metabolism and renal function in type 2 diabetic mice. Mita, Y., et al, Biological Trace Element Rese

Effects of Chromium Picolinate and Biotin Combination on Glycosylated Hemoglobin and Plasma Glucose in Subjects with Type 2 Diabetes Mellitus with Baseline HbA1c (> 10%). Albarracin, C, Endocrine Soc Proceedings 2005, P3-423

Cellular Chromium Enhances Activation of Insulin Receptor Kinase. Wang, H., et al, Biochemistry 2005; Page Est. 8.7

Pharmacological effects of biotin. Fernandez-Mejia, Cristina, Jur Nutritional Biochemistry 2005; 16: 424-427

Low toenail chromium concentration and increased risk of nonfatal myocardial infarction. Guallar, E., et al, The EURAMIC Study. Am J Epidemiol 2005; (162):157-164

Role of chromium in human health and in diabetes. Cefalu, W. T., et al, Diabetes Care 2004; 27 (11):2741-2751;

Lower toenail chromium in men with diabetes and cardiovascular disease compared with healthy men.Rajpathak, S., et al, Diabetes Care 2004; 27(9): 2211-2216

Effects of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Rabinovitz, H., et al, Int, J, Vitam, Nutr. Res. 2004; 74 (3):178-182

Glycemic Control is Improved by the Combination of Chromium Picolinate and Biotin in Type 2 Diabetes Mellitus.Albarracin, C, (Diabetes 52 Suppl 2); A587; (abstr) 2483; 2004

Improvement in Fasting Blood Glucose with the Combination of Chromium Picolinate and Biotin in Type 2 Diabetes Mellitus. Geohas, J, Diabetes 2004; 52 (suppl 2): A45; (abstr 191)

Effect of Chromium Picolinate and Biotin on Post Prandial Hyperglycemia in Moderately Obese Subjects with Type 2 Diabetes Mellitus.Komorowski, J R, Obesity Res 2004; 12

Program Including Chromium Picolinate and Biotin Combination Decreases Fasting and Post Prandial Glucose Levels in People with Type 2 Diabetes Mellitus. Future, V, Diabet & Vasc Dis Res. 2004; 1( 1): 53

Chromium supplementation improves insulin resistance in patients with T2 DM.Morris, B. W, Diabetic Medicine 2000; (17) 684-686

Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium.Ravina, A., et al, Diabetic Medicine 1999; (16):164-167

High dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes. McCarty, M. F, Medical Hypotheses 1999;

Chromium supplementation for women with gestational diabetes mellitus. Jovanovic, L., et al, 1999; The Journal of Trace Elements in Experimental Medicine (12):91-97

Biotin Regulation of Pancreatic Glucokinase and Insulin in Primary Cultured Rat Islets and in Biotin-Deficient Rats* Endocrinology, Romero-Navarro, G., et al , 1999; 140 (10): 4595-4600

Chromium, glucose intolerance and diabetes. Anderson, R. A., Journal of the American College of Nutrition 1998; 17(6):548-555

Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes.Anderson, R. A., et al, Diabetes 1997; (46):1786-1791

A High Biotin Diet Improves the Impaired Glucose Tolerance of Long-Term Spontaneously Hyperglycemic Rats with Non-Insulin-Dependent Diabetes Mellitus. Zhang, H., et al, 1996; J. Nut Sci. Vitaminol.,

Biotin for diabetic peripheral neuropathy. Koutsikos, D., et al, Biomed & Pharmacother 1990; 44: 511-514

Biotin Status and Plasma Glucose in Diabetes. Coggeshall, J.C, Ann NY Acad Science 1985; 447: 398-392

Biotin Deficiency during Total Parenteral Nutrition: Its Clinical Manifestation and Plasma Nonesterified Fatty Acid Level. Matsusue, S. et al, 1985; J.of Parenteral & Enteral Nut. Vol 9: 671-763

Biotin and glucose metabolism. Dakshinamurti, K., et al, Can. Journal Biochemistry 1970; Vol 48: 493-500