Safety

A significant body of peer-reviewed data from studies conducted over a 30+ year period confirms chromium picolinate is a safe nutritional supplement. With evidence that includes several published clinical, in vivo and in vitro studies conducted by leading scientists worldwide, chromium picolinate's safety profile has been affirmed by experts and international regulatory authorities.

No toxic effects of oral biotin have been reported in humans. Oral intakes of up to 10 mg for six months have not produced adverse effects, demonstrating that biotin must have an extremely low order of toxicity.

Lack of mutagenicity of chromium picolinate in the hypoxanthine phosphoribosyltransferase gene mutation assay in Chinese hamster ovary cells. , Mutation Research 2005; (58):86-95

Determining the safety of chromium tripicolinate for addition to foods as a nutrient supplement. Berner, T. O., et al,Food and Chemical Toxicology 2004; (42):1029-1042

Expert Group on Vitamins and Minerals - Risk Assessment - Biotin. Safe upper levels of vitamins
and minerals. Food Standard Agency 2003 - UK: 36-41

Cosmetic Ingredient Review Expert Panel - Final Report on Safety Assessment of Biotin. Fiume, M. Z., International Journal of Toxicology 2001; 20(suppl 4): 1-12

Supplementation with chromium picolinate recovers renal Cr concentration and improves carbohydrate metabolism and renal function in type 2 diabetic mice. Mita, Y., et al, Biological Trace Element Rese